Spinal Anesthesia Associated With General Anesthesia in Coronary Artery Bypass
试验速览
- 阶段
- 4 期
- 状态
- 已完成
- 发起方
- 入组人数
- 60
- 试验地点
- 4
- 主要终点
- consumption of fentanyl citrate in intra-operative in Coronary Artery Bypass Grafting surgery with cardiopulmonary bypass under spinal anesthesia associated with general anesthesia.
研究概览
简要总结
CONTEXT: In patients eligible for coronary artery bypass surgery, anesthesia should provide a number of conditions that exceed the limits of cardiovascular stability, myocardial protection and other organs. Moreover, the combination of general anesthesia and spinal anesthesia lessens the homeostatic, metabolic, hormonal and immunosuppressive changes. The goal of this research was to evaluate the consumption of fentanyl citrate in intra-operative in Coronary Artery Bypass Grafting (CABG) surgery with cardiopulmonary bypass under spinal anesthesia associated with general anesthesia.
METHODS: Clinical, prospective, randomized and double covered study, approved by the Research Ethics Committee. Fifty-six patients candidates for CABG with CPB, after signing the Terms of consent, were randomized and divided into two groups: GI - General and GII - General + subarachnoid. General anesthesia was induced according to the weight of each patient and maintenance with isoflurane and fentanyl. Spinal anesthesia was induced with 20 mg of 0.5% hyperbaric bupivacaine and 200 mcg of morphine, the patient is placed in cephalo-position slope of 45 degrees for 10 minutes in Group II. In the statistical study was performed using the Mann-Whitney test; the level of statistical significance was set at 5%.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 盲法
- Double (Participant, Investigator)
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Patients of both genders
- •Underwent cardiac artery bypass surgery with cardiopulmonary bypass, with
- •No restriction on age
- •No restriction on ethnicity
- •No restriction on education or social class
排除标准
- •Patients with sternotomy provided; those
- •Urgent surgery and/or emergency
- •Patient was with signs of shock
- •Patients with chronic renal failure
- •Patients with liver disorders
- •Tracheostomy patients
- •Patients with presence of use of mechanical ventilatory support;
- •Patients with physical disabilities; bedridden and wheelchair users.
- •Patients to withdraw the Consent and Informed
- •Patients who eventually had to be re-operated in the presence also of the mechanical ventilatory support.
结局指标
主要结局
consumption of fentanyl citrate in intra-operative in Coronary Artery Bypass Grafting surgery with cardiopulmonary bypass under spinal anesthesia associated with general anesthesia.
时间窗: in 24 hours
Will be measure the consumption of fentanyl in 24 hours
次要结局
未报告次要终点
研究者
Daniel Gioielli de Castilho
MD
Universidade do Vale do Sapucai