NCT02890407已完成不适用
Genetics of Aortic Stenosis: From Family Forms to the Common Forms
适应症
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 1,987
- 试验地点
- 3
- 主要终点
- identify the genetic factors involved in the occurrence of aortic stenosis
研究概览
简要总结
The association study will compare the allele frequencies of polymorphisms of a single nucleotide (SNP) in the population of individuals with aortic stenosis compared to a control population.
Patients will be included only if they are suffering from a typical form of tight and surgical tricuspid aortic stenosis. Patients will therefore only included if they are suffering from aortic stenosis, the surface is less than 1 cm² and if histological analysis or failing intraoperative findings of the surgeon showed a tricuspid aortic stenosis.
研究设计
- 研究类型
- Observational
- 观察模型
- Family Based
- 时间视角
- Retrospective
入排标准
- 年龄范围
- 65 Years 至 —（Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Criteria has reached:
- •That patients are operated or not, they can be considered as having a degenerative aortic stenosis, patients will be diagnosed with aortic stenosis (aortic area <1 cm) without obvious cause found.
- •criteria not met
- •Strictly normal aortic valve by ultrasound in an over 65-year-old patient.
- •All patients do not fit into the above two categories are considered as having an unknown phenotype and will not be used in binding assays. In particular, the presence of an aortic sclerosis or even moderate aortic regurgitation can be considered as potentially incipient form of aortic stenosis, patients with this type of anomaly will not be scanned during family analyzes.
排除标准
- •Patients who did not sign the consent
- •Non degenerative aortic stenosis or for which another cause could be found.
- •Among the most commonly found causes are:
- •Bicuspid aortic valve
- •Severe renal impairment
- •Severe Hypercholesterolemia
结局指标
主要结局
identify the genetic factors involved in the occurrence of aortic stenosis
时间窗: 36 months
次要结局
未报告次要终点
研究者
研究点 (3)
Loading locations...
相似试验
Unknown
不适用
The Correlation Between Genetic Polymorphism, Platelet Activity, Clopidogrel Responsiveness, and Serum Adipokine Concentration in Asian Acute Coronary Syndrome PatientsChronic Coronary Artery DiseaseAcute Coronary SyndromeNCT01255267China Medical University Hospital
招募中
不适用
Genetic Architecture of Acute Aortic Syndromes and Aortic Aneurysm.Acute Aortic DissectionThoracic Aortic AneurysmNCT06353607University Hospital, Basel, Switzerland730
已完成
不适用
Phenotype/Genotype Correlation in a Family With Early Onset OsteoarthritisOsteoarthritisNCT01999166University Hospital, Caen5
已完成
不适用
Genetic Susceptibility to Rheumatic Heart Disease in the Pacific RegionRheumatic Heart DiseaseMitral StenosisNCT02188862University of Oxford2,372
已完成
不适用
Genetic Polymorphism and Parkinson's Disease in TaiwaneseParkinson's DiseaseNCT01996878Changhua Christian Hospital334