Baroreceptor Function and Inflammation in Relation to Orthostatic Intolerance During Early Mobilization After Elective Hip Arthroplasty
试验速览
- 阶段
- 不适用
- 入组人数
- 30
- 试验地点
- 1
- 主要终点
- Change in baroreceptor function from preoperatively to 6 hours after surgery
研究概览
简要总结
The purpose of this observational study is to evaluate the baroreceptor function in relation to surgical inflammation and orthostatic intolerance after elective hip arthroplasty.
The main hypothesis is that baroreceptor function is attenuated after surgery and related to surgical inflammation.
详细描述
Orthostatic intolerance and hypotension is prevalent during early mobilization after major surgery.
This observational study aims to evaluate the baroreceptor function during using a standardized evaluation protocol before, 6- and 24 hours after elective primary unilateral hip-arthroplasty.
The study hypothesis is that baroreceptor function as expressed by the valsalva ratio is attenuated after surgery and related to surgical inflammation.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Scheduled for unilateral hip arthroplasty
- •18 years or older
- •Able to give informed consent
排除标准
- •American Society of Anesthesiologists (ASA) class 3 or higher
- •Chronic arrythmia (Atrial fibrillation or other arrythmia)
- •Incompensated ischaemic heart disease
- •Mobilization restriction due to surgical reasons
- •Medical complications during admission requiring transferral to other department
结局指标
主要结局
Change in baroreceptor function from preoperatively to 6 hours after surgery
时间窗: 6 hours after surgery
Change in baroreceptor function as expressed by change in the blood pressure valsalva ratio during a standardized assessment before and 6 hours after surgery.
次要结局
- Orthostatic Hypotension(Preoperative, 6 and 24 hours postoperative.)
- Orthostatic response in blood pressure(Preoperative, 6 and 24 hours after surgery)
- Inflammatory markers(preoperative, 6 and 24 hours postoperative)
- Orthostatic response in heart rate variability(preoperative, 6 and 24 hours postoperative)
- Orthostatic intolerance(preoperative, 6 and 24 hours after surgery)
- Baroreceptor function(On the day of surgery: preoperatively, 6- and 24 hours after surgery)
研究者
Oeivind Jans
M.D., Research Fellow
Rigshospitalet, Denmark