Role of the Environment and Endocrine Disruptors in Child Cryptorchidism
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 入组人数
- 1,452
- 试验地点
- 1
- 主要终点
- frequency of the job exposure of the parents of endocrine disruptors
研究概览
简要总结
Cryptorchidism is the most frequent congenital defect of the male newborn. It requires surgery in childhood, increases the risk of fertility disorders and cancer. As a major public health objective, it's the subject of numerous recommendations. Its frequency is increasing in some countries faster than a single genetic cause could not explain it. It may occurs in a geographic cluster. The cause of cryptorchidism involves genetic, hormonal and environmental factors. Animal studies suggest that endocrine disruptors interfere with fetal testicular migration. The aim of the study is to find out if some environmental exposition may be associated with cryptorchidism.
详细描述
Cryptorchidism is the most frequent congenital defect of the male newborn. It requires surgery in childhood, increases the risk of fertility disorders and cancer. As a major public health objective, it's the subject of numerous recommendations. Its frequency is increasing in some countries faster than a single genetic cause could not explain it. It may occurs in a geographic cluster. The cause of cryptorchidism involves genetic, hormonal and environmental factors. Animal studies suggest that endocrine disruptors interfere with fetal testicular migration. The aim of the study is to find out if some environmental exposition may be associated with cryptorchidism.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Prospective
入排标准
- 年龄范围
- 1 Month 至 18 Years（Child, Adult）
- 性别
- Male
- 接受健康志愿者
- 否
入选标准
- 未提供
排除标准
- 未提供
结局指标
主要结局
frequency of the job exposure of the parents of endocrine disruptors
时间窗: 1 day
Measure of the frequency of endocrine disruptors assessed by european questionary QLK4-1999-01422 (simplified version )
次要结局
- identify food exposure criteria (phytoestrogen or EDC pesticides) associated with the presence of a cryptorchid.(1 day)
- Constitution of collection of biological samples from children with non-palpable bilateral cryptorchidism(1 day)
- comparison of cryptorchid and non-cryptorchid children born to parents with isolated exposure vs multiple exposures(1 day)
- Comparison of frequencies of exposure to endocrine disruptors (Environmental Disrupting Chemicals) in parents giving birth to a congenital cryptorchid child vs child not cryptorchid at birth but with secondary cryptorchidism.(1 day)