Effect of angiotensin II receptor type 1 blocker and branched-chain amino acids on small intestinal pathological lesions in patients with liver cirrhosis - Effect of ARB and BCAA on small intestine of cirrhotic patients

The third department of internal medicine, Nara Medical University0 个研究点目标入组 120 人开始时间: 2013年10月21日最近更新: 2023年10月17日

适应症

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•1) Patients with malignant tumor 2) Patients with severe heart disease 3) Patients with severe and active infectious disease except viral hepatitis 4) Patients with HIV 5) Patients with severe renal dysfunction 6) Patienst with intracranial tumor 7) Patients with on going refractory hepatic coma 8) Patients with refractory ascites and pleural effusion 9) Patients with crutial digestive bleedings within 4 weeks 10) Ptients with intravascular thrombosis within 6 months except portal thrombosis 11) Patients with the following issues a. Systemic chemotherapy against HCC b. Partial hepatectomy or local treatment against HCC within 4 weeks c. Being treated with anticoagulant drugs d. Being treated with invasive surgical therapy within 4 weeks e. Having been treated with organ transplantation f. Being treated with bone marrow transplantation within 4 weeks 12) Patients with oral intake difficulty 13) Patients with severe digestive diseases 14) Patients taking a tablet which would affect this clinical study 15) Patients without normal absorbing function 16) Patients having been resistered in other clinical study within 4 weeks 17) Pregnant woman, lactating woman, or a woman suspected of pregnancy 18) Patients with severe allergic reaction 19) Patients with drug abuse or psycological disorders 20) Patients taking aliskiren hemifumarate 21) Patients concluded to be inappropriate to participate in this study by their physitians

发起方

The third department of internal medicine, Nara Medical University