Cold Induced Activation of Brown Fat in Winter Swimmers
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 15
- 试验地点
- 2
- 主要终点
- 5. Difference in brown adipose tissue (BAT) activity after cooling between Winter Swimmers (WS) and No-Winter Swimmers (NWS).
研究概览
简要总结
This study investigates cold-induced brown fat activation in winter swimmers and not-winter swimmers by skin temperature measures assessed with infra red thermography imaging and skin temperatures. Winter swimmers and not-winter swimmers will participate in an acute cooling intervention and thermoneutral intervention for comparison of energy expenditure and skin temperatures at the supraclavicular area.
详细描述
The field of human brown adipose tissue (BAT) research is focused on activation of BAT as a means of manipulating energy expenditure and potentially anti-obesity and anti-diabetic properties of the tissue. This is well established in rodent studies and explained as due to the specific brown fat uncoupling protein 1 (UCP1). Despite increasing evidence that indicates a metabolic regulatory role of BAT in humans, BAT activation/recruitment is not fully understood.
Cold induced brown fat activity will be measured by skin temperature measures by means of infra-red thermography imaging and skin temperature.
15 healthy male winter swimmers and 8 healthy male non-winter swimmers (controls) will be included in the study.
研究设计
- 研究类型
- Interventional
- 分配方式
- Non Randomized
- 干预模型
- Factorial
- 主要目的
- Basic Science
- 盲法
- Single (Outcomes Assessor)
入排标准
- 年龄范围
- 18 Years 至 35 Years（Adult）
- 性别
- Male
- 接受健康志愿者
- 是
入选标准
- •Age 18-35 years. Men Caucasian white Body Mass Index 19-25 kg/m
- •Moderate physical activity level (not more than 8-10 hours of training pr. Week) Ability to give informed consent. Ability to follow verbal and written instructions in Danish. Body fat percent under 21% measured at the pre-examination day. Winter swimmers: Min. 2 swim/ week. Swimming in winter-season in open water outdoor in Denmark from September/October until study start in March.
- •Not-winter swimmers: Not winter-swimmers or taken cold showers on a regular basis.
排除标准
- •Chronic diseases: Hormonal: Metabolic Diseases mb. Graves, hypothyroidism, myxedema and goiter. Diabetes Melitus, Coronary heart disease (history of myocardial infarction, unstable angina pectoris, or congestive heart failure), cancer treated within last 3 years.
- •Tobacco, marijuana or intravenous drug use within 1 year of screening. Dieting, recent weight loss (>3 kg within 3 month) or a history of an eating disorder.
- •Dietary supplements. History of depression, psychosis, or other psychiatric illness requiring hospitalization.
- •Alcohol consumption >14 units/week. History of alcohol abuse within the past 3 years. Known liver disease or elevated liver biomarkers more than 2 times upper normal levels in the preliminary investigation.
- •Known kidney disease or elevated kidney biomarkers, in the preliminary investigation.
- •Use of daily medications, except for seasonal use of antihistamines. Diagnosed sleep disturbances.
结局指标
主要结局
5. Difference in brown adipose tissue (BAT) activity after cooling between Winter Swimmers (WS) and No-Winter Swimmers (NWS).
时间窗: Difference in peak temperature after 2 hours of cooling.
BAT activity is measured by skin temperature in the supraclavicular BAT depot using infrared thermography imaging. Difference between peak temperature change (peak temperature minus baseline temperature) during 2 hours of cooling is calculated.
次要结局
- Difference in glucose control between WS and NWS.(Difference in glucose control between WS and NWS after a 2 hours glucose tolerance test under thermoneutral conditions.)
- Difference in resting energy expenditure after cooling versus no cooling(Difference in resting energy expenditure after 2 hours of cooling versus 2 hours of no cooling.)
研究者
Susanna Søberg
Principal Investigator
Rigshospitalet, Denmark