Influence of Mango Intake on Skin Health in Postmenopausal Women
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 36
- 试验地点
- 1
- 主要终点
- Skin carotenoid
研究概览
简要总结
This study aims to investigate the effects on 16 weeks of mango intake on skin health in postmenopausal women. Half of the participants will receive 85g portions of mangoes while the other half receive 250g portions of mangos. Participants will be instructed to consume the specific portion 4 times a week, for a total duration of 16 weeks.
详细描述
Mangoes are rich in carotenoids, flavonoids, vitamins and other active phytochemicals such as resistant starches. Although a role of mangoes in skin health has long been advocated in traditional medicine, little scientific research has been conducted.
We hypothesize that 85g (0.5 cups) of mango intake for 16 weeks will have minimal impact on skin health, while 250g (1.5 cups) of mango intake will produce significant benefits.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Basic Science
- 盲法
- None
入排标准
- 年龄范围
- 50 Years 至 70 Years（Adult, Older Adult）
- 性别
- Female
- 接受健康志愿者
- 是
入选标准
- •Postmenopausal
- •Fitzpatrick skin type I and II
- •BMI 18.5 - 35.0 kg/m2
- •Normal blood levels in the comprehensive metabolic panel, or values slightly out of range as approved by the study physician
排除标准
- •Allergic to mangoes
- •Fruit consumption of 2 or more cups per day
- •Vegetable consumption of 3 or more cups per day for females
- •Fruit juice consumption of more than 1 cup per day
- •Self-reported malabsorption
- •Currently taking regular prescription drugs i.e. statins, thyroid, anti-inflammatory drugs
- •Had any medical or cosmetic procedures such as laser resurfacing or plastic surgery to the face within the last 6 months, including botulinum toxin, dermal fillers, collagen or other similar cosmetic procedure
- •Autoimmune photosensitive condition or known genetic condition with a deficiency in collagen production (such as Ehler-Danlos)
- •Smoking (current smoker, smoked within the past year, former smokers with greater than a 20 pack-year history of smoking within the past 20 years.
- •Indications of substance or alcohol abuse
- •Unwillingness to discontinue high antioxidant supplements during washout and interventions
研究组 & 干预措施
High mango group
250g (1.5 cup) of mango intake per day, 4 days a week for 16 weeks
干预措施: 16 weeks mango intake (Other)
Low mango group
85g (0.5 cup) of mango intake per day, 4 days a week for 16 weeks
干预措施: 16 weeks mango intake (Other)
结局指标
主要结局
Skin carotenoid
时间窗: 0, 4, 8, 12, and 16 weeks
Using a skin photometer (Veggie Meter) to measure change in skin carotenoid within a period of 16 weeks.
Skin Wrinkle Depth and Redness
时间窗: 0, 8, and 16 week
Using a skin camera from BrighTex Bio-Photonics to measure change in skin wrinkle depth and redness within a period of 16 weeks.
次要结局
- Sebum(0, 8, 16, weeks)
- Plasma carotenoid(0, 8, 16 weeks.)