NCT07619300尚未招募不适用
Pilot Study: Dorsal Root Ganglion Stimulation After Spinal Cord Injury-Related Lower Motor Neuron Damage
Peter J. Grahn, Ph.D.1 个研究点 分布在 1 个国家目标入组 1 人开始时间: 2026年12月1日最近更新:
干预措施
试验速览
- 阶段
- 不适用
- 状态
- 尚未招募
- 发起方
- 入组人数
- 1
- 试验地点
- 1
研究概览
简要总结
The purpose of this study is to study sensorimotor circuit activity generated in response to temporarily implanted dorsal root ganglion stimulation by recording from muscles of the lower extremities as well as functional outcomes achieved over a 10-day rehabilitation program in an individual with lower motor neuron injury.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Basic Science
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 70 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Traumatic and non-traumatic spinal cord injury (SCI)
- •ASIA Impairment Scale (AIS) A-D
- •SCI below the tenth thoracic vertebral level
- •Greater than 1 year post-SCI
- •Intact spinal reflexes at or below injury level in 1 or more muscles
排除标准
- •Currently a prison inmate, or awaiting trial, related to criminal activity
- •Pregnancy at the time of screening for trial enrollment
- •Active, untreated urinary tract infection
- •Unhealed decubitus ulcer
- •Unhealed skeletal fracture
- •Spinal abnormality that may impede percutaneous implantation of spinal electrodes
- •Untreated clinical diagnosis of psychiatric disorder
- •Joint contractures that impede typical range of motion
- •Non-MRI-compatible implanted medical devices
- •Other implanted stimulation devices (e.g., deep brain stimulator, cardiac pacemaker, diaphragmatic pacer, etc.)
- •Active participation in an interventional clinical trial which, based on the research team's assessment, may compromise protocol compliance, safety, and/or validity of data collected during this study
- •History of clinically diagnosed cardiopulmonary disorder, such as severe orthostatic hypotension, which may impede participation in rehabilitation activities such as changes in body position such as supine-to-sit-to-stand activities, prolonged standing, or stepping
- •History of frequent and/or severe autonomic dysreflexia
- •History of seizure disorder
- •Any illness or condition which, based on the research team's assessment, will compromise with the patient's ability to comply with the protocol, patient safety, or the validity of the data collected during this study
研究组 & 干预措施
Dorsal Root Ganglion Stimulation
Experimental
One adult patient with spinal cord injury below T10 will be treated with dorsal root ganglion stimulation.
干预措施: Abbot Dorsal Root Ganglion Neurostimulator (Device)
研究者
Peter J. Grahn, Ph.D.
Principal Investigator
Mayo Clinic
研究点 (1)
Loading locations...
相似试验
尚未招募
2 期
Effect of Electrical Stimulation During Functional Proprioceptive Neuromuscular Facilitation Training on Hand Function and Spasticity Among Individuals with Sub Acute StrokeCTRI/2025/12/098799Nongmaithem Pujan Devi36
已完成
不适用
Biomechanical and Functional Effects of Adding Sensory-Threshold Electrical Stimulation to Neurodevelopmental Therapy in Children With Spastic Cerebral Palsy: A Single-Arm Repeated-Measures StudySpastic Cerebral Palsy (sCP)NCT07491341Harran University11
招募中
不适用
Sensorimotor Technique on Navicular Drop in School Going ChildrenNCT07576504Riphah International University22
尚未招募
2/3 期
Effect of transcranial direct current stimulation Combined with Mental Practice in improving upper limb muscle Strength and Function in People with Spinal Cord injury.CTRI/2025/10/09614120
招募中
不适用
Treatment of Cognitive and Sensorimotor Deficits in Parkinson's Disease With High Definition Transcranial Direct Current StimulationPARKINSON DISEASE (Disorder)NCT07534397The University of Texas at Dallas20