Incomplete Total Body Protein Recovery in Adolescent Patients With Anorexia Nervosa
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 154
- 主要终点
- Change in Total Body protein
研究概览
简要总结
The study aimed to assess protein accretion during weight gain in adolescent patients with Anorexia nervosa
详细描述
Background: Bone health and growth during adolescence require adequate Total Body Protein (TBPr). Re-nutrition for patients with anorexia nervosa (AN) should aim to normalize body composition, i.e. recovery of fat mass and TBPr.
Objective
The study intended to analyze predictors of protein status, including exercise status, in adolescents with AN, and to investigate whether weight gain would replete body protein deficits.
Methods: The investigators assessed TBPr in a longitudinal, observational study as height-adjusted nitrogen index (NI) using in-vivo neutron activation analysis in adolescents with AN at the commencement of refeeding (T0), as well as seven months thereafter (T1), and in age-matched normal weight controls. Lean tissue and fat mass were assessed with Dual-Energy X-Ray Absorptiometry (DXA). BMI, BMI-SDS and lean tissue mass were tested as predictors of protein status using Receiver Operating Characteristic (ROC) analysis.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 12 Years 至 19 Years（Child, Adult）
- 性别
- Female
- 接受健康志愿者
- 是
入选标准
- •diagnosis of anorexia nervosa (DSM-IV)
- •aged 12 - 19 years
- •female gender
排除标准
- •existence of a further disease with effect on body composition
- •no known disease
- •normal weight
结局指标
主要结局
Change in Total Body protein
时间窗: Between baseline (inpatient admission) and at 7 months follow-up
Change in Total Body protein
次要结局
- Change in body weight(Between baseline (inpatient admission) and at 7 months follow-up)
- Change in Body Mass Index(Between baseline (inpatient admission) and at 7 months follow-up)
- Change in body fat mass(Between baseline (inpatient admission) and at 7 months follow-up)
- Change in body lean tissue mass(Between baseline (inpatient admission) and at 7 months follow-up)
研究者
Dr. Verena Haas
Principle Investigator, Clinical Researcher
Charite University, Berlin, Germany