Inferior Vena Cava Indexes (Collapsibility, Distensibility, Delta) in Positive Pressure Supports and Prediction Ability of Intravascular Volume Status in ICU Patients
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 100
- 试验地点
- 1
- 主要终点
- Determine the effect of positive pressure on IVC collapsibility index
研究概览
简要总结
Collapsibility (CI-IVC), distensibility (dIVC) and delta (ΔIVC) indices, which are dynamic measures of inferior vena cava (IVC) diameter, are used to assess the intravascular volume status in critically ill patients. Positive pressure support (PS) has been shown to induce IVC diameter distention by increasing intrathoracic pressure, and high positive expiratory pressure (PEEP) decreases the CI-IVC percentage (4). During Triggered positive pressure support it is necessary to clarify which IVC index is valid for measuring the volume status.it is aimed to compare the IVC indexes (CI-IVC, DIVC, ΔIVC), positive rate of change with pressure, correlation with central venous pressure and accurate prediction of volume status in patients with different positive pressure support.
详细描述
The IVC diameters at different pressure supports were measured by the same clinician after obtaining a clear image of where the US and IVC measurements were made and the probe stabilization was achieved. He performed the procedure of changing the pressure supports, a blind independent intensive care physician without working, and recorded the applied pressure supports respectively. The different pressure supports applied are as follows:
- PS 10 mmHg-PEEP 5 mmHg,
- PS 0 mmHg- PEEP 5 mmHg
- PS 10 mmHg- PEEP 0 mmHg.
- T-tube (PS 0 mmHg-PEEP 0 mmHg)
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Age>18 years
- •Current use of mechanical ventilation through an endotracheal tube.
排除标准
- •Profound Hypoxia defined as a fraction of inspired oxygen requirement >90% or a PEEP >10 mmHg
- •Patient-ventilator desynchrony or active agitation
- •Unstable O2 requirement
- •Cardiovascular instability
- •Current PEEP requirements of >10 mmHg
- •Current oxygen saturation (SpO2) of <88%.
- •High intra abdominal pressure
- •Right cardiac failure
- •Morbid obesity
结局指标
主要结局
Determine the effect of positive pressure on IVC collapsibility index
时间窗: 12 month
Determine the effect on CI-IVC of an increase in positive end-expiratory pressure and pressure support
Determine the effect of positive pressure on IVC distensibility index
时间窗: 12 month
Determine the effect on distensibility index of an increase in positive end-expiratory pressure and pressure support
Determine the effect of positive pressure on IVC delta index
时间窗: 12 month
Determine the effect on delta index of an increase in positive end-expiratory pressure and pressure support
次要结局
- Determine the effect of positive pressure on central venous pressure(12 month)
研究者
Aykut Saritas
Principal Investigator
Tepecik Training and Research Hospital