The Effects of Different Ventilation Modes on Patients With Plasma Inflammatory Factor and Respiratory Function in Patients With Pulmonary Lobe Resection
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 发起方
- 入组人数
- 102
- 试验地点
- 1
- 主要终点
- Clinical Pulmonary Infection Score
研究概览
简要总结
The objective of this study was to discuss the effects of different ventilation modes on patients with plasma inflammatory factor and respiratory function in patients with pulmonary removal.
详细描述
Patients who meet the inclusion criteria will be numbered in the order of admission, and a dedicated person will prepare codes and opaque envelopes for random allocation. This study was divided into 3 groups, one groups was ventilation side volume control ventilation+continuous positive pressure ventilation on the non ventilation side, the other groups was ventilation side volume control ventilation+continuous positive pressure ventilation on the non ventilation side; the other groups was ventilation side pressure regulated volume control ventilation+continuous positive pressure ventilation on the non ventilation side.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Sequential
- 主要目的
- Other
- 盲法
- Triple (Participant, Investigator, Outcomes Assessor)
盲法说明
The researchers in this study enrolled suitable patients using a random number table method before surgery, and then performed different intraoperative single lung ventilation modes according to the grouping after unblinding the patients upon entering the room. The postoperative follow-up personnel or data analysts are unaware of the grouping status.
入排标准
- 年龄范围
- 18 Years 至 75 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Comprehensive examination and analysis of imaging, laboratory examination and other comprehensive examinations, the diagnosis is clear, which is in line with lobe resection surgical indications
- •Age 18-75 years old, the gender is not limited;
- •ASA grading Ⅰ ~ III level;
- •It is expected that the single lung ventilation time is ≥1 hours, and ≤3 hours
排除标准
- •Emergency surgery;
- •There is a taboos on the existence of systemic anesthesia;
- •There is a history of acute chronic upper respiratory infections in the past January;
- •Previous bronchial asthma, chronic obstructive pulmonary disease, bronchial dilatation, phthisis ,aspergillosis , acute respiratory distress syndrome or history of respiratory failure;
- •Merge the function of important organs such as heart, liver, and kidney;
- •There was a history of chest surgery and the history of trauma;
- •Preoperative lung function test obvious abnormal abnormal abnormalities (1 second of exhalation (FEV1) <60%);
- •Patients refuse to participate in the clinical trial
结局指标
主要结局
Clinical Pulmonary Infection Score
时间窗: Within 15 days after surgery
The clinical pulmonary infection score index is mainly used to evaluate the severity of pulmonary infection, which involves many factors, including: body temperature, white blood cell count, tracheal secretions, oxygenation, X-ray chest X-ray, and the progress of pulmonary infiltrates. The maximum score is 12 points, and the severity of infection is directly proportional to its score.
次要结局
未报告次要终点
研究者
Mao Enting
Anesthesiology resident,Affiliate Hospital of Zunyi Medical University
Zunyi Medical College