Expression of Trim25 in Peripheral Blood Mononuclear Cells of Patients With Sepsis and Non-sepsis and Its Relationship With the Prognosis of Patients With Sepsis
试验速览
- 阶段
- 不适用
- 状态
- Enrolling By Invitation
- 入组人数
- 65
- 试验地点
- 1
- 主要终点
- TRIM25 in PBMCs
研究概览
简要总结
Sepsis is a life-threatening condition caused by the body's overwhelming response to infection, which can lead to organ damage and failure. The goal of this observational study is to better understand the underlying biological changes that occur in patients with sepsis compared to those who do not have the condition.
We will collect peripheral blood samples from patients diagnosed with sepsis and from non-sepsis control participants. From these samples, we will isolate peripheral blood mononuclear cells (PBMCs) and serum.
We will then analyze these components to measure the activity of specific genes and the levels of key inflammatory factors (cytokines).
The information we gather will help researchers identify molecular and inflammatory markers associated with sepsis. This knowledge is crucial for developing new and more effective methods for diagnosing and treating this critical illness.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 70 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •1. SOFA score >=2;
- •Aged 18-70 years male and female;
- •Hospitalization.
排除标准
- •1. Immune system disease, such as HIV;
- •Disease that possibly affect the function of immune system, such as tumor and chronic viral infection;
- •Patients that treated with massive cortical hormone (>200mg/d) or immunosuppressant;
- •Pregnant or lactation women.
结局指标
主要结局
TRIM25 in PBMCs
时间窗: From 2021.12 to 2026.06
We will collect peripheral blood mononuclear cells (PBMCs) from both sepsis patients and non-sepsis control patients to compare the expression level of the TRIM25 gene in these cells.
次要结局
未报告次要终点