Postoperative Pain Alleviation in Patients Undergoing Cardiac Surgery; Presternal Bupivacaine and Magnesium Infiltration Versus Conventional Intravenous Analgesia
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 90
- 试验地点
- 1
- 主要终点
- postoperative pain
研究概览
简要总结
Effective pain relief after cardiac surgery has assumed importance with the introduction of fast track discharge protocols that requires early weaning from mechanical ventilation. Inadequate pain control reduces the capacity to cough, mobility, increases the frequency of atelectasis, and prolongs recovery. Infiltration of local anesthetics near the surgical wound has shown to improve early postoperative pain in various surgical procedures.
Magnesium is the fourth most plentiful cation in our body. It has antinociceptive effects in animal and human models of pain.
详细描述
Effective pain relief after cardiac surgery has assumed importance with the introduction of fast track discharge protocols that requires early weaning from mechanical ventilation. Inadequate pain control reduces the capacity to cough, mobility, increases the frequency of atelectasis, and prolongs recovery.
A major cause of pain after cardiac surgery is the median sternotomy particularly on the first two postoperative days.
The most often used analgesics in these patients are parenteral opioids which can lead to undesirable side-effects as sedation, respiratory depression, nausea, and vomiting.
Infiltration of local anesthetics near the surgical wound has shown to improve early postoperative pain in various surgical procedures.
Magnesium is the fourth most plentiful cation in our body. It has antinociceptive effects in animal and human models of pain.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Double (Participant, Investigator)
入排标准
- 年龄范围
- 18 Years 至 60 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •18-60 years old
- •American Society of Anesthesiologists physical status II and III
- •Patients scheduled for open heart valve replacement surgery with sternotomy
排除标准
- •Emergency surgery
- •Clinically significant kidney or liver disease
- •Patients allergic to local anesthetic
- •Patients with prolonged CPB time (>120 min)
- •Patients required intra-aortic balloon pump
研究组 & 干预措施
group A
( bupivacain 0.125% magnesium sulfate 5%) infusion in the presternum , for 48 hours
干预措施: bupivacain with magnesium sulphate (Drug)
group B
bupivacaine 0.125% infusion in the presternum , for 48 hours
干预措施: Bupivacaine only (Drug)
Group C
will be conventional , will receive postoperative fentanyl , paracetamol , and ketorolac.
干预措施: conventional (Drug)
结局指标
主要结局
postoperative pain
时间窗: 48 hours postoperative
Vas Scale
次要结局
- extubation time(48 hours)
- Fentanyl consumption(48 hours)
研究者
Emad Zarief , MD
lecturer of anesthesia and ICU
Assiut University