Association of Nocturnal Hypoxemia and Benign Prostatic Hyperplasia in Patients With Obstructive Sleep Apnea
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 91
- 试验地点
- 1
- 主要终点
- correlation between sleep related Hypoxemia and Benign Prostatic hyperplasia in Patients with OSA
研究概览
简要总结
- Obstructive Sleep apnea (OSA) is a common sleep disorder characterized by frequent partial or complete obstructions of the upper airway during sleep leading to sleep fragmentation and sympathetic activation.
- The main pathophysiological findings in OSAS are due to both a dynamic obstruction of the upper airway and the fragmentation of sleep during the night. These issues result in abnormal cycles of hypoxia and re-oxygenation. This disturbance produces transient ischemia of the tissues, a concept known as chronic intermittent hypoxia (CIH) with clinical implication in several cardiometabolic diseases
- Polysomnography (PSG) is considered to be the gold standard for diagnosing sleep-related breathing disorders, which include obstructive sleep apnea (OSA), central sleep apnea, sleep-related hypoventilation disorders, and sleep related hypoxia disorder
- Benign prostate hyperplasia (BPH) is the most frequent benign neoplasm in aging men and one of the most common chronic conditions in the male population.
- Although the pathogenesis of BPH is not yet fully understood, recent evidence indicates the role of chronic inflammation in BPH, CIH which occurred in OSA patient induces systemic inflammatory processes; such chronic inflammatory conditions may contribute to tissue injury, activate cytokines release, increase the concentration of growth factors, and subsequently cause the development of BPH.
- To date, little research has focused on the relationship between OSA and BPH, especially the impact of nocturnal hypoxemia , sleep architecture ,hormonal disturbance on BPH . Therefore, the aim of our study is to illuminate association between sleep related hypoxemia and BPH in Patients with OSA
详细描述
All patients enrolled in the study underwent the following assessment:
- Full History taking with stress on patient Complaint:
Witnessed apneas during sleep. Awakening with choking or gasping sensation Loud habitual Snoring Dry mouth falling asleep during driving or motor vehicle Accidents Frequent nocturia Tiredness and Sleepiness in morning after sleep at night Awakening with a headache. Insomnia 2. Clinical examination:
- General examination: Respiratory rate, O2 saturation, blood pressure, heart rate, lower limb edema, neck vein, thyroid enlargement, any facial deformities.
- Anthropometric measurements:
• Height (in meters): patients stand up straight, with buttocks, shoulder blades, and heels touching the back of the stadiometer.
研究设计
- 研究类型
- Observational
- 观察模型
- Other
- 时间视角
- Cross Sectional
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- Male
- 接受健康志愿者
- 否
入选标准
- 未提供
排除标准
- 未提供
结局指标
主要结局
correlation between sleep related Hypoxemia and Benign Prostatic hyperplasia in Patients with OSA
时间窗: 13 month
sleep related hypoxemia can be assessed through parameters recorded during a diagnostic polysomnogram (PSG): * The oxygen desaturation index (ODI) : represents the number of times per hour of sleep that a patient's oxyhemoglobin saturation drops by more than a specified amount from baseline, typically 4%. * Mean SpO2 (%): The average oxygen saturation for the entire night. * T 90%: The percentage of total sleep time spent with oxygen saturation \<90%. * Apnea hypopnea time % (AHT%): The percentage of total sleep time spent with apnea and hypopnea duration in patients with OSA
次要结局
未报告次要终点