A randomized, double-blind, placebo-controlled, pilot experiment of individualized homoeopathic medicines in knee osteoarthritis

D N De Homoeopathic Medical College and Hospital0 个研究点目标入组 0 人开始时间: 待定最近更新: 2021年11月24日

试验速览

暂无简介。

•1. Age 50-70 years
•2. Patients of either sex
•3. Diagnosed knee OA as per American College of Rheumatology (ACR) clinical/radiographic classification criteria:
•a) Knee pain
•b) At least 1 of 3: age more than 50 years, stiffness less than 30 min, and crepitus on knee motion
•c) Osteophytes on knee x-ray
•4. Patients already undergoing regular oral or topical analgesics or NSAID therapy for painful episodes of OA, provided the medications are stopped completely at least 2 weeks prior study entry
•5. Literate patients; can read Bengali or English
•6. Providing written informed consent

•1. Severe degeneration of knee joint with marked joint narrowing, varus, or valgus deformity of knee ( >12Â°), evidenced by imaging or other evidences and requiring surgical intervention
•2. Non-ambulant patients
•3. Self-reported joint disorders other than osteoarthritis (e.g., inflammatory joint disease, specific arthropathy, hyperuricaemia and/or gout, severe axis deviations or instabilities, joint or skin infections, joint prostheses of the lower limbs)
•4. Intra-articular injections within 2 weeks before study entry
•5. Transplanted knees
•6. Recent significant knee surgery within last 6 months
•7. Patients who are too sick for consultation
•8. Unwilling to take part and not giving consent to join the study
•9. Unable to read patient information sheet
•10. Diagnosed cases of unstable mental or psychiatric illness or other uncontrolled or life-threatening illness affecting quality of life
•11. Pregnancy, puerperium and lactation
•12. Substance abuse and/or dependence
•13. Self-reported immune-compromised state, and
•14. Undergoing homoeopathic treatment for any chronic disease within last 6 months.

发起方

D N De Homoeopathic Medical College and Hospital