Platelet Serotonin Deficiencies: the Strasbourg Experience
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 发起方
- 入组人数
- 50
- 试验地点
- 1
- 主要终点
- Score of ISTH BAT Hemorrhagic Questionnaire
研究概览
简要总结
Hemorrhagic syndromes are investigated using algorithms established by reference centers and hemostasis societies.
The investigation of platelet dense granules (nucleotide and serotonin testing) is part of the second-line tests.
It can be performed in cases of platelet aggregation abnormalities in platelet-rich plasma (PRP) suggesting a secretion abnormality, or in cases where the latter is normal, it can be performed if the patient's clinical presentation points to a primary hemostasis abnormality and the clinician wishes to pursue further investigations Intraplatelet serotonin deficiencies are often iatrogenic and may be accompanied by bleeding.
Their impact on platelet function is poorly documented.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Only
- 时间视角
- Retrospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Adult patient (≥ 18 years old)
- •Treated at Strasbourg University Hospital for a hemorrhagic syndrome, suggesting a primary hemostasis abnormality and normal von Willebrand factor, during the period from January 1, 2023, to April 1, 2024.
排除标准
- •- Refusal to participate in the study
结局指标
主要结局
Score of ISTH BAT Hemorrhagic Questionnaire
时间窗: Up to 12 months
ISTH BAT bleeding questionnaire with its 12-item grid scored from 0 to 4: A score ≥ 4 in men or ≥ 6 in women makes the presence of a constitutional hemostasis disorder highly probable
次要结局
未报告次要终点