Relationship Between Postoperative Cognitive Decline and Cytokines in Elderly Patients
试验速览
- 阶段
- 不适用
- 发起方
- 入组人数
- 300
- 试验地点
- 1
- 主要终点
- Differences in cytokines levels between the two groups
研究概览
简要总结
postoperative cognitive decline is a common and deleterious complication in aged patients.The link between inflammation and postoperative cognitive decline has also been reported.However,the link between SOD1，SOD2，Osteopontin， Kallikrein-6，and Contactin-1 and postoperative cognitive decline is unknown. In this project ,investigators examine the relationship between 5 cytokines measured at there timepoints (preoperative [PREOP], postoperative day 1 [POD1] , and postoperative day 3[POD2]) and postoperative cognitive decline among older adults undergoing orthopedic surgery.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Prospective
入排标准
- 年龄范围
- 65 Years 至 85 Years（Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •patients who are more than 65 years old
- •patients who undergo orthopedic surgery(trauma ,especially fracture of lower limb)
- •patients with ASA physical status I-III
- •patients who have a consent
排除标准
- •patients who are more than 85 years old
- •patients with ASA physical status >III
- •patients who have neurological disorders, stroke or other affective central nervous system diseases
- •patients who have a history of serious psychiatric illness
- •patients with long-term use of psychoactive substances
- •patients who undergo multiple trauma and the presence of head injury
结局指标
主要结局
Differences in cytokines levels between the two groups
时间窗: 72h after operation
Compare differences in cytokines levels between the two groups
次要结局
未报告次要终点
研究者
Jia-feng Wang
M.D
Changhai Hospital