Impact of Prognostic Factors on Treatment Outcomes in Patients With Cervical Degenerative Disc Disease Undergoing Anterior Cervical Discectomy and Fusion With the Bagby and Kuslich (BAK/C) Technique: A Retrospective Cohort Study
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 80
- 试验地点
- 1
- 主要终点
- Identification of Independent Risk Factors for Poor Surgical Outcomes
研究概览
简要总结
This retrospective study aimed to identify predictive prognostic factors for treatment outcomes in patients with cervical degenerative disc disease (CDDD). The study analyzed data from 80 patients who underwent anterior cervical discectomy and fusion (ACDF) with the Bagby and Kuslich (BAK/C) technique. Patients were stratified into two groups based on clinical outcomes at a 3-year follow-up, and logistic regression was used to determine which factors, such as age and bone mineral density, were independent predictors of poor recovery.
详细描述
Cervical degenerative disc disease (CDDD) is a prevalent condition causing significant pain and neurological dysfunction. Anterior cervical discectomy and fusion (ACDF) combined with the Bagby and Kuslich (BAK/C) interbody fusion technique is an established surgical treatment, but patient outcomes vary. This study was designed to address a gap in the literature by retrospectively analyzing both surgical and patient-related variables over a 3-year follow-up period to understand the factors influencing treatment success. A cohort of 80 patients treated between January and December 2020 was identified. Patients were divided into a "favorable outcome" group and a "poor outcome" group based on post-operative pain relief and neurological improvement (JOA score). The study's primary objective was to use multivariate logistic regression analysis to identify independent risk factors (e.g., age, bone mineral density, disease severity, postoperative complications) associated with poor outcomes. The findings aim to provide evidence-based insights to help optimize patient selection and treatment strategies for ACDF with BAK/C fusion.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Retrospective
入排标准
- 年龄范围
- 36 Years 至 75 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Patients aged ≥ 18, regardless of gender.
- •Diagnosed with degenerative cervical intervertebral disc disease based on clinical and imaging findings.
- •Significant pain and symptoms impacting quality of life, requiring surgery.
- •Undergoing anterior decompression and BAK/C interbody fusion.
- •Minimum 3-year follow-up data available.
排除标准
- •Serious cervical conditions (e.g., fracture, infection, tumor).
- •Previous cervical surgery or other treatments.
- •Pregnant or lactating women.
结局指标
主要结局
Identification of Independent Risk Factors for Poor Surgical Outcomes
时间窗: Assessed based on data collected up to the 3-year final follow-up
To identify predictors of poor treatment outcome using multivariate logistic regression analysis. The analysis evaluated variables including age, bone mineral density, baseline disease severity (initial JOA score), postoperative complications, and postoperative care. The outcome was being classified into the "Poor Outcome Group".
次要结局
- Change in Neurological Function(Baseline (preoperative), 1 week postoperative, 6 months postoperative, and 3-year final follow-up)
- Radiological Fusion Rate(Assessed at 6 months and at the 3-year final follow-up)
- Change in Intervertebral Height(1 week postoperative and 3-year final follow-up)
- Incidence of Postoperative Complications(Assessed throughout the 3-year follow-up period)
- Bone Mineral Density (BMD)(Baseline (Preoperative))
研究者
Liang Hao
Principal Investigator
The Third Hospital of Shijiazhuang