Characterization of the Methylation Profile of Samples Stored at the Biological Resource Center (CRB) of the Rizzoli Orthopedic Institute (IOR)
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 90
- 试验地点
- 1
研究概览
简要总结
The project, funded by the PNRR under Mission 4 "Education and Research," aims to strengthen the network of Italian biobanks by improving data management in accordance with the FAIR principles (Findable, Accessible, Interoperable, Reusable). The University of Trento has issued a call for proposals to support Italian biobanks in characterizing samples and expanding associated datasets using advanced technologies.
The Biological Resource Center at the Rizzoli Orthopedic Institute in Bologna participated in this call for proposals, requesting funding to analyze the DNA methylation profiles of three patient cohorts: those with inflammatory/degenerative diseases, sarcomas, and rare genetic musculoskeletal disorders. This study will contribute to understanding the biological significance of methylation and exploring its diagnostic and therapeutic potential.
The initiative aims to generate data useful for personalized medicine and improve the management of the diseases involved.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Retrospective
入排标准
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Be a patient with a sample stored in one of the biobanks belonging to the CRB IOR
- •Have one of the following conditions: a rare skeletal disorder, sarcoma, or inflammatory arthritis.
排除标准
- •Patients who have refused to consent to the use of their samples or the processing of their data for genetic studies
- •Patients who have refused to consent to the transfer of their samples outside the IOR
研究者
Luca Sangiorgi
coordinator of CRB
Istituto Ortopedico Rizzoli