Prospective Study ofPhoton Counting Computed Tomography in Acute Coronary Syndrom Patients
试验速览
- 阶段
- 不适用
- 状态
- 尚未招募
- 发起方
- 入组人数
- 180
- 试验地点
- 1
- 主要终点
- Major Adverse Cardiovascular Events, MACE
研究概览
简要总结
For patients with severe calcification or complex non-calcified plaques, we investigate wether PCCT can enable non-invasive, in vivo precise differentiation and quantitative measurement of plaque components (e.g., spotty calcification, necrotic core, fibrous tissue). Further we also study wether these quantitative imaging features can independently predict the risk of MACE in the short term and long term
详细描述
Photon-counting detector CT (PCD-CT), as an innovative technology in the field of CT imaging, is gradually transforming the landscape of cardiac imaging. It differs significantly from conventional energy-integrating detector CT (EID-CT) in technical principles, bringing new possibilities for the diagnosis and assessment of heart diseases. This study will enrolled patients undergo standardized PCCT coronary angiography (CCTA) and make ultra-fine quantitative plaque analysis. Then at least 12 months of clinical follow-up will be performed. Finally correlation analysis between baseline plaque characteristics and follow-up endpoint events will be made.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Inclusion Criter:
- •Adult patients (≥18 years) with clinically diagnosed coronary artery disease or undergoing CCTA for chest pain/heart failure symptoms.
- •Able and willing to provide informed consent and complete scheduled follow-up visits.
排除标准
- •History of iodine contrast agent allergy.
- •Severe renal insufficiency (eGFR < 30 mL/min/1.73 m²).
- •History of prior coronary artery bypass grafting (CABG).
- •Pregnant or lactating women
研究组 & 干预措施
coronary artery disease patients referred to photon-counting CT examination
coronary artery disease patients who underwent photon-counting CT will be enrolled, a sub-specialty trained cardiac radiologist and a sub-specialty trained cardiologist will analyze the image from the photon counting CT scans in detail.
干预措施: there is no intervention in this study (Other)
结局指标
主要结局
Major Adverse Cardiovascular Events, MACE
时间窗: 12months
Non-fatal myocardial infarction Non-fatal stroke Cardiovascular death Revascularization Acute heart failure
次要结局
未报告次要终点
研究者
Jing Ma
chief physician
Chinese PLA General Hospital