Relative Sarcopenia and Cardiometabolic Risk in Young Adults With Obesity
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 28
- 试验地点
- 1
- 主要终点
- Percent Change in Serum Myostatin Levels From Pre- to 3 Hours Post-exercise
研究概览
简要总结
The goal of this research study is to learn more about the hormones that muscles make during exercise, and if those hormones are associated with type 2 diabetes risk in adults who are overweight or obese. Participants will undergo exercise testing on an upright bicycle, with blood samples taken for muscle hormones before and after exercise. The hypothesis is that adults with overweight/obesity and insulin resistance will have an impaired muscle hormone profile in response to exercise compared to adults with overweight/obesity who are not insulin resistant.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Cross Sectional
入排标准
- 年龄范围
- 18 Years 至 70 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Previously enrolled in protocol 2004P000013 or protocol 2012P002276, which had overweight or obesity as inclusion criteria
- •Ability to walk up 3 flights of stairs and 3 city blocks (to ensure ability to complete exercise testing)
排除标准
- •Unstable heart or lung disease
- •Exercise >150 minutes/week
- •Participation in college sports
结局指标
主要结局
Percent Change in Serum Myostatin Levels From Pre- to 3 Hours Post-exercise
时间窗: Pre- to 3 hours post-exercise
Percent change in serum myostatin levels from pre- to 3 hours post-cardiopulmonary exercise test
次要结局
- Percent Change in Serum Myostatin Levels From Immediately Post to 2 Hours Post-exercise(Immediately post to 2 hours post-exercise)
- Percent Change in Serum Myostatin Levels From Pre- to 2 Hours Post-exercise(Pre- to 2 hours post-exercise)
研究者
Melanie Schorr Haines, M.D
Principal Investigator
Massachusetts General Hospital