Relationships Between Vitamin D and Orthopedic Trauma
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 100
- 试验地点
- 2
- 主要终点
- Vitamin D levels at the time of the index injury through one year post-operative follow up.
研究概览
简要总结
Vitamin D is an essential hormone involved in bone metabolism, bone mineral density maintenance, and bone health. Vitamin D deficiency is putatively linked to poor pediatric orthopedic outcomes [1]. Further, the risk of low vitamin D associated fractures may be greater in minority pediatric populations [2]. In adults, utility of vitamin D alleles as a biomarker for bone density and fracture risk has been debated for over 10 years [3-5]. Peak bone density is achieved at 25 years old; however, most orthopedic trauma patients less than 25 years of age present with substantial vitamin D deficiencies.
详细描述
- INTRODUCTION 1.1. Background Vitamin D is an essential hormone involved in bone metabolism, bone mineral density maintenance, and bone health. Vitamin D deficiency is putatively linked to poor pediatric orthopedic outcomes [1]. Further, the risk of low vitamin D associated fractures may be greater in minority pediatric populations [2]. In adults, utility of vitamin D alleles as a biomarker for bone density and fracture risk has been debated for over 10 years [3-5]. Peak bone density is achieved at 25 years old; however, most orthopedic trauma patients less than 25 years of age present with substantial vitamin D deficiencies.
1.2. Aim(s)
- Identify the prevalence of vitamin D deficiency in young trauma patients with fractures.
- Describe the merits of vitamin D supplementation in healing and long-term outcomes ≤25 year old trauma patients with fractures.
1.3. Rationale for the study Occurrence of stress and low energy mechanism fractures within a population at peak bone density is troubling and suggestive of underlying pathology. Understanding how to combat vitamin D deficiency, and improve outcomes, is essential in the development of comprehensive and preventative trauma care.
1.4. Hypothesis 1.4.1. Primary Hypothesis Patients aged ≤25yrs old with fractures will have low vitamin-D levels. 2. OBJECTIVES AND STUDY OUTCOME MEASURES 2.1. Study Objectives 2.1.1. Primary Objective Determine the frequency of vitamin D deficiency in fracture patients aged less than 25 years old.
2.1.2. Secondary Objective Report the long-term (one year) outcomes for fracture healing relative to baseline and therapeutic vitamin D levels.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Only
- 时间视角
- Retrospective
入排标准
- 年龄范围
- 18 Years 至 25 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Patients must be >18 years old and ≤25 years old
- •Patients must have any fracture requiring follow-up
- •Patients must have received vitamin-D assessment
排除标准
- •Patients aged >25yrs
- •Prisoners
结局指标
主要结局
Vitamin D levels at the time of the index injury through one year post-operative follow up.
时间窗: February 2016 and February 2020
Vitamin D levels at the time of the index injury through one year post-operative follow up.
次要结局
- Patient demographics(February 2016 and February 2020)
- injury characteristics(February 2016 and February 2020)
- mortality(February 2016 and February 2020)
- admit information(February 2016 and February 2020)
- rate of nonunion(February 2016 and February 2020)
- discharge disposition(February 2016 and February 2020)
- payer type(February 2016 and February 2020)