PhotoDynamic Therapy for Line Infection Prevention (PLIP): Pilot Study on Normal Volunteers
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 10
- 主要终点
- Evaluation of the skin microbiome after methylene blue treatment
研究概览
简要总结
We are evaluating the effect of methylene blue and visible light activation on the microbiome of the skin.
详细描述
Antiseptics are routinely utilized to prevent infections of vascular catheters. We are evaluating the addition of methylene blue and light activation on skin to determine whether this inexpensive and non-toxic treatment can decrease skin pathogens and prevent blood stream infections of long-term vascular catheters. This is a pilot study of normal volunteers to determine the effect on the microbiome of the addition of methylene blue and light activation on antiseptic-treated skin.
研究设计
- 研究类型
- Interventional
- 分配方式
- Non Randomized
- 干预模型
- Single Group
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 21 Years 至 60 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Normal individuals without skin problems
排除标准
- •Diabetics
- •Atopic dermatitis
- •G-6-PD deficiency
- •Other skin conditions
- •Allergies to methylene blue or chlorhexadine
结局指标
主要结局
Evaluation of the skin microbiome after methylene blue treatment
时间窗: 1 week
We compared the two arms of each subject --one arm treated with chloraprep and a biopatch \[routine treatment of skin\] to the routine treatment with the addition of methylene blue spray and light activation. The microbiome of both skin areas were assessed before and after the routine treatment and the treatment with the addition of methylene blue therapy;
次要结局
未报告次要终点
研究者
Jeanine Wiener-Kronish
Chief of Anesthesia
Massachusetts General Hospital