Later Life Cognitive Impairment, Proprioception, and Biomarkers in Former NHL Players Who Suffered Multiple Concussions
试验速览
- 阶段
- 不适用
- 状态
- 终止
- 入组人数
- 6
- 试验地点
- 1
- 主要终点
- Cognition assessed with the Montreal Cognitive Assessment Scale
研究概览
简要总结
To investigate long term affects of multiple concussions on the cognition, balance, proprioception, and biomarkers in retired National Hockey League players
详细描述
This research study will collect data for each subject in one single visit. During the visit the subject will be asked to consent to the study which is estimated to take approximately 10 minutes. A medical history will be obtained, taking approximately 15 minutes. Blood, urine, and cheek swabs will be collected for approximately 15 minutes. The PHQ-9, Becks Depression Inventory, Connors Adult ADHD Rating Scale (CAARS™), and Montreal Cognitive Assessment (MoCA) will be administered, these assessments combined are estimated to take 50 minutes. Lastly, patients will be asked to complete a Sensory Organization Test (SOT) which takes approximately 15 minutes. There are only licensed health professionals working on this project that will respect your privacy and conduct this trial following all HIPPA and clinical research guidelines.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Other
入排标准
- 年龄范围
- 40 Years 至 80 Years（Adult, Older Adult）
- 性别
- Male
- 接受健康志愿者
- 是
入选标准
- •Retired professional NHL player
- •History or reported concussion and concussion like symptoms
排除标准
- •Any neurological condition
- •Non sport related head trauma
结局指标
主要结局
Cognition assessed with the Montreal Cognitive Assessment Scale
时间窗: 10 minutes
Montreal Cognitive Assessment Scale
次要结局
- Human Interleukin-6 (IL-6)(5 Minutes)
- Patient Health Questionnaire 9 (PHQ-9)(5 minutes)
- S-100B Calcium binding protein(5 minutes)
- Total Tau Protein (tTAU)(5 minutes)
- Adult Attention Deficit assessed with the Connors' Adult Attention Deficit Disorder Rating Scale(10 minutes)
- Interleukin 7 (IL-7)(5 minutes)
- 8-iso-Prostaglandin F2a(5 minutes)
- Dityrosine(5 minutes)
- Proprioception/Postural Stability assessed with the Sensory Organization Test(15 minutes)
- MicroRNA miR132(5 minutes)
- Brain derived neurotrophic factor (BDNF)(5 minutes)
- Beck's Depression Inventory(10 minutes)
- 3-nitrotyrosine(5 minutes)
- Apolipoprotein E-4(5 minutes)
- MicroRNA miR183(5 minutes)
- Amyloid beta 40(5 minutes)
- Eco-Rna Species(5 minutes)
- Human 8-hydroxy-2' -deoxyguanosine (8-OHdG)(5 minutes)
- Complement Component 3 B (C3b)(5 minutes)
研究者
Joanne DiFrancisco-Donoghue
Assistant Professor, Ph. D.
New York Institute of Technology