NCT01899716已完成不适用
Exercise and Severe Depression: Clinical and Biological Analysis
适应症
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 50
- 试验地点
- 2
- 主要终点
- Depressive symptoms
研究概览
简要总结
The study aimed to evaluate the use of exercise as a complementary strategy to treat severe major depression in inpatients.
Hypothesis: Exercise can be used as a safe and efficacious complimentary strategy in severe depressed inpatients.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Single (Outcomes Assessor)
入排标准
- 年龄范围
- 18 Years 至 60 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Diagnosis of Major Depressive Disorder according to M.I.N.I (DSM-IV) criteria American Psychiatry Association(1994)
- •score of 25 or more on Hamilton-17
- •not being involved in other physical activity programs during the hospitalization
- •aged between 18 and 60 years
- •being able to read, understand, and provide written informed consent
排除标准
- •have three or more cardiovascular risk factors according to Physical Activity Readiness Questionnaire (PAR-Q)
- •are unable to exercise due other clinical condition
- •have diagnosis of Schizophrenia, Bipolar disorder or current use of alcohol or other drugs according to M.I.N.I DSM-IV criteria American Psychiatry Association(1994)
- •if they are taking beta-blocking medications
结局指标
主要结局
Depressive symptoms
时间窗: 2 weeks of hospitalization (14 days)
Hamilton 17 for depression
次要结局
- Brain-Derived Neurotrophic Factor(BDNF)(Baseline, after 2 weeks of hospitalization and at discharge (participants will be followed for the duration of hospital stay, an expected average of 3 weeks))
- Thiobarbituric acid reactive substances(TBARS)(Baseline, after 2 weeks of hospitalization and at discharge (participants will be followed for the duration of hospital stay, an expected average of 3 weeks))
- Quality of Life(Baseline, after 2 weeks of hospitalization and at discharge (participants will be followed for the duration of hospital stay, an expected average of 3 weeks))
- Depressive symptoms at discharge (participants will be followed for the duration of hospital stay, an expected average of 3 weeks)(Discharge)
研究者
研究点 (2)
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