Enterovirus- and parechovirus infection in Dutch children: epidemiology, diagnosis and prognosis - Enterovirus- and parechovirus infection in children

Sint Elisabeth Ziekenhuis0 个研究点目标入组 240 人开始时间: 待定最近更新: 2024年6月11日

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•A + B are required;A. All Children <= 16 years of age with a clinical suspicion of an EV/HPeV infection:
•1. Fever (temperature >=38,0°C )
•2. Meningeal inflammation: (anamnestic or with examination at least 2 of the following: headache, photophobia, nuchal rigidity, irritability, lethargy, nausea, vomiting, drowsiness, positive sign of Kernig or Brudzinsky) OR
•3. At least 3 of the following: hypothermia, headache, drowsiness, nuchal rigidity, irritability, photofobia, vomiting, diarrhea, anorexia, couhing, myalgia, rash OR
•4. Sepsis: Clinical suspicion of an infection plus:
•- temperature >38,5°C of < 36°C rectal or oral
•- tachycardia: heart rate > 2 SD for age OR children < 1 year with a bradycardia: heart rate < 2 SD for age
•- tachypnea: breathing rate> 2 SD for age ;B. Signed informed consent by the parent(s)/legal guardian(s)

•- Other proven cause of the infection: positive bacterial, viral (other than EV/HPeV), parasitic or fungal/yeast culture or PCR (feces, urine, throat swab, blood, CSF).
•- Other causes of illness: neoplasma, auto-immune diseases, rheumatic diseases, endocrinologic diseases, gastrooesophageal reflux, etcetera
•- Known psycho-motor retardation, metabolic diseases with neuro-muscular or cognitive abnormalities
•- Patients older than 16 years of age
•- No signed informed consent from the parent(s)/ legal Guardian(s)

发起方

Sint Elisabeth Ziekenhuis