NCT03309839已完成不适用
HLA-DR Expression in Neonates After Cardiac Surgery Under Cardiopulmonary Bypass
适应症
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 50
- 试验地点
- 1
- 主要终点
- HLA-DR expression
研究概览
简要总结
The purpose of this study is to determine how monocyte HLA-DR and other markers of immune function change with time in neonates who underwent cardiac surgery with cardiopulmonary bypasss.
We hypothesize that HLA-DR expression in neonates is predictive of septic complications after cardiopulmonary bypass
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- — 至 28 Days（Child）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Patients aged ≤ 28 days
- •Admission after cardiac surgery under cardiopulmonary bypass
排除标准
- •Lack of parental consent
结局指标
主要结局
HLA-DR expression
时间窗: Preoperatively, and 1, 2, 3 and 4 days after the end of cardiopulmonary bypass
Number of HLA-DR molecules per monocyte (AB/c) determined by flow cytometry on whole blood using a Quantibrite phycoerythrin fluorescence quantitation kit (BD Biosciences) Number of HLA-DR molecules per monocyte (AB/c) determined by flow cytometry on whole blood using a Quantibrite phycoerythrin fluorescence quantitation kit (BD Biosciences)
次要结局
- Cytokines measurements(Preoperatively, and 1, 2, 3 and 4 days after the end of cardiopulmonary bypass)
研究者
研究点 (1)
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