A Registered Observational Cohort Study on α-Synucleinopathy
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 入组人数
- 500
- 试验地点
- 1
- 主要终点
- UPDRS /UMSARS scores
研究概览
简要总结
α-Synucleinopathy is a cluster of neurodegenerative disease with motor and non-motor symptom. The data to be collected is intended to help healthcare providers make important medical decisions concerning α-synucleinopathy, through an enhanced understanding of the natural history, progression and multi-omics datasets of α-synucleinopathy.
详细描述
α-Synucleinopathy is a cluster of neurodegenerative disease with motor and non-motor symptom, including Parkinson's disease (PD), multiple system atrophy (MSA) and dementia with lewy bodies (DLB). The data to be collected is intended to help healthcare providers make important medical decisions concerning α-synucleinopathy, through an enhanced understanding of the natural history, progression and multi-omics datasets of α-synucleinopathy. Datas will be accumulated retrospectively at research entry and prospectively during follow up.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 30 Years 至 80 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Participants with a clinical diagnosis of primary α-synucleinopathy
- •Unrelated healthy controls
排除标准
- •Patients with secondary α-synucleinopathy that cannot be excluded.
- •Patients with other neurological disorders.
- •Pregnant or lactating women.
结局指标
主要结局
UPDRS /UMSARS scores
时间窗: Baseline
Disease severity was evaluated by the neurologist using the united Parkinson's disease rating scale (UPDRS) or united multiple system atrophy rating scale (UMSARS) separately as diagnosed.
次要结局
- ACE-III scores(Baseline)
- MoCA scores(Baseline)
- HRV (ms)(Baseline)
- Plasma α-synuclein levels (ng/ml)(Baseline)
- H&Y stage(Baseline)
- Mean arterial pressure after 3 minutes of upright posture versus decubitus position (mmHg)(Baseline)
- PAF (Hz)(Baseline)
- Vic(1 year after Baseline)