Distribution and Prognostic Impact of Oncogenic Drivers in Metastatic Lung Adenocarcinoma : a Retrospective Monocentric Study in Nancy University Hospital Center
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 114
- 试验地点
- 1
- 主要终点
- Overall survival
研究概览
简要总结
The recent discovery of oncogenic drivers has revolutionized the management of advanced lung cancer by development of tyrosine kinase inhibitors targeted therapies. Prevalence of daily tobacco use is evaluated at 31,3 % in Grand-Est region, the only French region with a statistically significative difference for smoking habits. This region shows a higher incidence (+ 13 %) and mortality for lung cancer in comparison to the average for other French regions. The objectives of our studie were to estimate the distribution of oncogenic drivers and analyse their prognostic impacts in the Nancy University Hospital Center metastatic lung adenocarcinoma's population.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Retrospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Lung adenocarcinoma
- •Patients diagnosed at a metastatic stage
- •Patient who benefited an oncogenic driver research on their histologic samples
- •Medical follow-up entirely done in Nancy Central Hospital
排除标准
- •Patients with double histology
- •Synchronous cancer
- •Patients with surgical care
结局指标
主要结局
Overall survival
时间窗: over a period of 5 years (Day 0 = anatomopathological diagnosis)
Time (in months) from anatomopathological diagnosis to death
Progression Free survival
时间窗: over a period of 5 years (Day 0 = anatomopathological diagnosis)
Time (in months) from anatomopathological diagnosis to progression of the disease assessed by RECIST criteria
Distribution in percentage of main oncogenic drivers in histological samples from metastatic lung adenocarcinoma
时间窗: At base line (Day 0 = anatomopathological diagnosis)
Distribution in percentage of main oncogenic drivers (KRAS, EGFR, ALK, ROS-1, BRAS and HER2), assessed by Sanger sequencing or FISH method in histological samples from metastatic lung adenocarcinomas
次要结局
- Distribution in percentage of metastasis sites according oncogenic drivers(At baseline (Day 0 = anatomopathological diagnosis))