Effects Of Dexmedetomidine On Succinylcholine-Induced Myalgia And Creatine Phosphokinase Levels In The Early Postoperative Period.
试验速览
- 阶段
- 不适用
- 状态
- 尚未招募
- 发起方
- 入组人数
- 60
- 试验地点
- 1
- 主要终点
- Dexmedetomidine helps reduce the myalgia caused by succinylcholine administered during induction of general anesthesia.
研究概览
简要总结
Succinylcholine chloride is a short acting depolarizing neuromuscular blocking agent. It is used to expedite rapid sequence endotracheal intubation and facilitate surgical procedures. However, it has a few reported adverse effects including fasciculations, postoperative myalgia, and an increase in serum Creatine phosphokinase. Dexmedetomidine is an alpha 2 receptor agonist with a notable anti-inflammatory response, which may diminish the succinylcholine-induced myalgia and the rise in Creatine phosphokinase.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 盲法
- Participant and Investigator Blinded
入排标准
- 年龄范围
- 18.00 Year(s) 至 60.00 Year(s)（—）
- 性别
- All
入选标准
- •Patients undergoing elective surgery (defined as a procedure that is not an emergency and can be scheduled in advance) under general anaesthesia.
- •American Society of Anesthesiologists (ASA) I & II.
排除标准
- •Any contraindications to general anesthesia.
- •Sensitivity or allergy to any of the study drugs.
- •Patients with elevated CPK levels pre-operatively – polytrauma, Crush injuries.
- •Morbid obesity.
- •Patients on anti-psychotic medication.
结局指标
主要结局
Dexmedetomidine helps reduce the myalgia caused by succinylcholine administered during induction of general anesthesia.
时间窗: Immediate post operatively and 24 hours post operatively
次要结局
- Succinylcholine causes mylagia which can be correlated with rise in creatine phospokinase levels in the serum(Immediate Pre-operative and 24 hours post-operative.)
研究者
Rachel B Singh
Christian Medical College and Hospital Ludhiana