Impact of Familial Cancer Specialist Recommendation on Chemoprevention Prescribing for Familial Breast Cancer (FBC) Risk in Primary Care: Short Survey and Interrupted Time Series Analysis
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 50
- 试验地点
- 1
- 主要终点
- Chemoprevention medication prescribing rates in primary care by area in England
研究概览
简要总结
Some women are more likely to get breast cancer as it runs in their family, they are at risk of familial breast cancer. There are medications, called chemoprevention, which may lower their risk of developing breast cancer by a third. However chemoprevention can also cause serious side effects, like womb cancer and blood clots. This makes decision to start them difficult. Researchers found that not all women who can have these medications are on them.
The investigators want to ask familial breast cancer specialists whether they recommend general practitioners (GP) to prescribe chemoprevention, by sending them a short survey. These specialists look after women where breast cancer runs in the family. The specialists assess a women's chance of getting breast cancer and advice those with increased risk what can be done to prevent breast cancer.
The investigators will then look at whether specialist recommendation makes a difference to whether GPs prescribe chemoprevention medication. This will be done by linking the specialists' survey response to information on GP prescribing that the government regularly publishes. This may help the investigators understand why chemoprevention is not used as often as it potentially can be.
详细描述
Phase I: Short survey of lead clinicians of familial cancer services, descriptive analysis of recommendations by areas of the country
Phase II: Prescribing data analysis (using OpenPrescribing) comprising:
- t-test to compare the chemoprevention prescribing rate in general practices where chemoprevention is recommended versus not recommended;
- interrupted times series analysis to assess the change in the chemoprevention prescribing after recommendation from specialist compared with changes occurring in practices where chemoprevention is not recommended and
- panel regression across all practices, in order to distinguish the relative impacts of national versus local recommendation, and the change over time.
研究设计
- 研究类型
- Observational
- 观察模型
- Other
- 时间视角
- Cross Sectional
入排标准
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Lead clinicians of NHS familial cancer services across England
- •Standard general practices (classed as type 4 by NHS Digital, to exclude walk-in centres, prisons, care homes, etc.) with prescribing data for chemoprevention available on OpenPrescribing
排除标准
- •General practices with less than 10 female patients aged 35 to 44 registered
- •General practices which cannot be linked to any familial cancer service from survey responses
结局指标
主要结局
Chemoprevention medication prescribing rates in primary care by area in England
时间窗: post specialist recommendation over 24 months
2.1. The chemoprevention prescribing rate in general practices where chemoprevention is recommended versus not recommended. The rate will be measured as the number of average daily quantities (ADQs) of chemoprevention prescribed per 1000 registered female patients aged between 35 and 74 per practice. For our primary outcome we will measure only tamoxifen items, and assess other therapies used in chemoprevention in supplementary analyses. 2.2. The change in chemoprevention prescribing rate (described in outcome 2.1) in general practices after recommendation from local specialist, compared with changes occurring in practices where chemoprevention is not recommended. 2.3. The relative change in the chemoprevention prescribing rate (described in outcome 2.1) in general practice in response to local recommendation, compared with change occurring in response to national recommendation.
Proportion of specialist service that recommends chemoprevention prescribing by areas in England
时间窗: 2019
Proportion of specialist service that recommends chemoprevention prescribing by areas in England, measured using survey questionnaire
次要结局
未报告次要终点