Effect of Using Nanochitosan Versus Calcium Hydroxide as Intracanal Medications on the Postoperative Pain and Apical Bone Healing
试验速览
- 阶段
- 不适用
- 入组人数
- 60
- 主要终点
- change in postoperative pain after intervention of chitosan: NRS
研究概览
简要总结
Effect of Using Nanochitosan versus Calcium Hydroxide as Intracanal Medications on the Postoperative Pain and Apical Bone Healing
详细描述
PICO approach P (population): maxillary anterior teeth having necrotic pulp with symptomatic apical periodontitis with evidence of apical radiolucency (minimum size 2 mm x 2 mm).
I (intervention):0.2% nanochitosan as intracanal medication. C (control): calcium hydroxide paste intracanal medication.
O (outcome):
Primary outcome: postoperative pain at time interval 4, 12, 24, 48, 72 hours
Secondary outcome:
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Double (Participant, Outcomes Assessor)
盲法说明
participants should be blinded
入排标准
- 年龄范围
- 20 Years 至 40 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- 未提供
排除标准
- 未提供
研究组 & 干预措施
chitosan
chitosan as intracanal medication 0.2% in form of gel
干预措施: Chitosan (Drug)
calcium hydroxide
intracanal medication
干预措施: Calcium Hydroxide (Drug)
结局指标
主要结局
change in postoperative pain after intervention of chitosan: NRS
时间窗: 4,12,24,27 hours
pain assessed by numerical rating scale, pain will be assessed using a numerical rating scale (NRS) which is proven to be a simple, valid, and a reliable pain measurement tool. The NRS consists of a series of numbers from zero to 10 with the end-points representing the extremes of pain as "no pain" and "the worst possible pain". Patients will rank their pain level by making a mark on the number they thought it represented their pain. The pain intensity is assigned into four categorical scores: 1, no pain (score 0); 2, mild (scores 1-3); 3, moderate (scores 4-6); 4, severe (scores 7-10). Pain is evaluated preoperatively and postoperatively after the initial visit at 4, 12, 24, 48, 72 hours
次要结局
- change in healing of apical periodontitis(3,6,12 months)
研究者
ahmed abdelmonam abd elmougoud
Phd student, principle investigator
Cairo University