贝前列素

概览

Beraprost is a synthetic analogue of prostacyclin, under clinical trials for the treatment of pulmonary hypertension. It is also being studied for use in avoiding reperfusion injury.

作用机制

Beraprost acts by binding to prostacyclin membrane receptors ultimately inhibiting the release of Ca from intracellular storage sites. This reduction in the influx of Ca has been postulated to cause relaxation of the smooth muscle cells and vasodilation.

适应症

For the treatment of pulmonary hypertension.

• Cystic Fibrosis (CF)
• Pain
• Ulcers
• Sensations of cold