Testolactone
生产企业：Bristol myers squibb, Bristol myers squibb co
Testolactone is a medication used to treat advanced breast cancer.
Testolactone is a medication used to treat advanced breast cancer.
Although the precise mechanism by which testolactone produces its clinical antineoplastic effects has not been established, its principal action is reported to be inhibition of steroid aromatase activity and consequent reduction in estrone synthesis from adrenal androstenedione, the major source of estrogen in postmenopausal women. Based on in vitro studies, the aromatase inhibition may be noncompetitive and irreversible. This phenomenon may account for the persistence of testolactone's effect on estrogen synthesis after drug withdrawal.
For palliative treatment of advanced breast cancer in postmenopausal women.
