氟尼缩松

概览

Flunisolide is an inhaled corticosteroid used as a prophylactic therapy in the maintenance treatment of asthma.

作用机制

Flunisolide is a glucocorticoid receptor agonist. The antiinflammatory actions of corticosteroids are thought to involve lipocortins, phospholipase A2 inhibitory proteins which, through inhibition arachidonic acid, control the biosynthesis of prostaglandins and leukotrienes. The immune system is suppressed by corticosteroids due to a decrease in the function of the lymphatic system, a reduction in immunoglobulin and complement concentrations, the precipitation of lymphocytopenia, and interference with antigen-antibody binding. Flunisolide binds to plasma transcortin, and it becomes active when it is not bound to transcortin.

适应症

For the maintenance treatment of asthma as a prophylactic therapy.

• Allergic Rhinitis (AR)
• Asthma