苄硝唑

概览

Benznidazole is a trypanocidal agent used to treat Chagas disease.

作用机制

Benznidazole is thought to be reduced to various electrophilic metabolites by nitroreductases present in Trypanosoma cruzi . These metabolites likely bind to proteins, lipids, DNA, and RNA resulting in damage to these macromolecules. Benznidazole has been found to increase trypanosomal death through interferon-γ which is likely present in increased amounts due to inflammation caused by macromolecule damage . DNA in parasites affected by benznidazole has been found to undergo extensive unpacking with overexpression of DNA repair proteins supporting the idea of DNA damage contributing to the mechanism of the drug .

适应症

For use in the treatment of Chagas disease in children 2-12 years of age .

• Chagas' Disease caused by Typanosoma cruzi