青霉烯酰聚赖氨酸 (Pre-pen)

概览

Benzylpenicilloyl polylysine is a penicillin derivative used to determine penicillin allergies.

作用机制

The skin test for penicillin demonstrates the presence or absence of specific IgE antibodies to major and minor penicillin determinants. IgE antibodies to major determinants can be detected by using benzylpenicilloyl polylysine. A penicillin skin test predicts only the presence of IgE antibodies for the major or minor penicillin determinants at the time of application and does not predict the future development of IgE-mediated reactions during subsequent courses of penicillin. Benzylpenicilloyl polylysine reacts specifically with penicilloyl skin sensitizing antibodies (reagins) to produce immediate wheal and flare reactions which may reflect increased risk of allergic reactions to subsequent penicillin therapy.

适应症

For use as a adjunct in assessing the risk of administering penicillin (benzylpenicillin or penicillin G).

• Penicillin Allergy
• Beta-lactam antibiotic allergy