丙硫氧嘧啶

概览

Propylthiouracil is a thiourea antithyroid agent used to treat hyperthyroidism.

作用机制

Propylthiouracil binds to thyroid peroxidase and thereby inhibits the conversion of iodide to iodine. Thyroid peroxidase normally converts iodide to iodine (via hydrogen peroxide as a cofactor) and also catalyzes the incorporation of the resulting iodide molecule onto both the 3 and/or 5 positions of the phenol rings of tyrosines found in thyroglobulin. Thyroglobulin is degraded to produce thyroxine (T4) and tri-iodothyronine (T3), which are the main hormones produced by the thyroid gland. Therefore propylthiouracil effectively inhibits the production of new thyroid hormones.

适应症

Used to manage hyperthyroidism which is due to an overactive thyroid gland (Grave's disease).

• Hyperthyroidism
• Thyrotoxic crisis