桂利嗪

概览

Cinnarizine is a drug used for the management of labyrinthine disorder symptoms, including vertigo, tinnitus, nystagmus, nausea, and vomiting.

作用机制

Cinnarizine inhibits contractions of vascular smooth muscle cells by blocking L-type and T-type voltage gated calcium channels. Cinnarizine has also been implicated in binding to dopamine D2 receptors, histamine H1 receptors, and muscarinic acetylcholine receptors.

适应症

For the treatment of vertigo/meniere's disease, nausea and vomiting, motion sickness and also useful for vestibular symptoms of other origins.

• Balance Disorders
• Dizziness
• Motion Sickness
• Nausea
• Peripheral Arterial Disease (PAD)
• Raynaud's Phenomenon
• Vertigo
• Inadequate cerebral circulation
• Peripheral vasculopathy