非马沙坦

概览

Fimasartan is an angiotensin II receptor antagonist (ARB) used to treat hypertension and heart failure.

作用机制

Angiotensin II activates AR1 leading to vasoconstriction and increased noradrenaline release which further increases vasoconstriction via action at α1-adrenergic receptors . It also stimulates secretion of aldosterone which acts to increase sodium and water reabsorption in the renal tubules . Fimasartan bind to and antagonizes AR1 preventing vasoconstriction and reducing aldosterone secretion to increase natriuresis leading to a reduction in blood volume. Together these effects produce an anti-hypertensive effect.

适应症

Used for the treatment of hypertension and heart failure .

• Hypertension, Essential Hypertension