特布他林 (Bricanyl)

概览

Terbutaline is a beta-2 adrenergic agonist used as a bronchodilator and to prevent premature labor.

作用机制

Terbutaline is a selective beta-2 adrenergic receptor agonist. Agonism of these receptors in bronchioles activates adenylyl cyclase, increasing intracellular cyclic adenosine monophosphate (cAMP). Increased cAMP decreases intracellular calcium, activating protein kinase A, inactivating myosin light-chain kinase, activating myosin light-chain phosphatase, and finally relaxing smooth muscle in the bronchiole.

适应症

Terbutaline is indicated for prevention and reversal of bronchospasm in patients at least 12 years old, with asthma and reversible bronchospasm associated with bronchitis and emphysema.

• Asthma
• Bronchospasm
• Chronic Cough (CC)
• Chronic Obstructive Pulmonary Disease (COPD)
• Cough
• Premature Labour
• Productive cough