伏立康唑 (Vfend, Voriconazole Hikma (previously Voriconazole Hospira), Voriconazole Accord)

概览

Voriconazole is a triazole compound used to treat fungal infections.

作用机制

Voriconazole is used to treat fungal infections caused by a variety of organisms but including Aspergillus spp. and Candida spp. Voriconazole is a triazole antifungal exhibiting fungistatic activity against fungal pathogens. Like other triazoles, voriconazole binds to 14-alpha sterol demethylase, also known as CYP51, and inhibits the demethylation of lanosterol as part of the ergosterol synthesis pathway in yeast and other fungi. The lack of sufficient ergosterol disrupts fungal cell membrane function and limits fungal cell growth. With fungal growth limited, the host's immune system is able to clear the invading organism.

适应症

For the treatment of esophageal candidiasis, cadidemia, invasive pulmonary aspergillosis, and serious fungal infections caused by Scedosporium apiospermum and Fusarium spp.

• Aspergillosis of the Central Nervous System
• Aspergillosis of the Liver
• Candidemia
• Candidiasis
• Coccidioidomycosis
• Endocarditis caused by Aspergillus
• Esophageal Candidiasis
• Fungal Infections
• Fungal meningitis caused by Exserohilum Infection
• Fusarium infection
• Histoplasmosis
• Invasive Aspergillosis