Vibrio cholerae CVD 103-HgR strain live antigen (Vaxchora)

概览

Vibrio cholerae CVD 103-HgR strain live antigen is a live, attenuated vaccine indicated for active immunization against disease caused by Vibrio cholerae serogroup O1.

作用机制

Vibrio cholerae CVD 103-HgR strain live antigen contains live attenuated cholera bacteria (V. cholerae O1 classical Inaba strain CVD 103- HgR). As an oral vaccine, it works by mimicking the natural infection of V. cholerae to generate a mucosal gut immune response. Upon administration, live attenuate cholera bacteria replicate in the gastrointestinal tract, thereby inducing rapid serum vibriocidal antibody and memory B cell responses. However, the exact immune mechanisms that lead to protection against cholera are not yet determined. Compared to killed bacterial strains, live strains are more efficiently taken up by M cells in the intestine, which are the major antigen sampling cells in the gut.

适应症

Vibrio cholerae CVD 103-HgR strain live antigen is indicated for active oral immunization against infection caused by Vibrio cholerae serogroup O1 in patients between 2 and 64 years of age.

• Cholera caused by Vibrio cholerae serogroup O1