塞利洛尔

概览

Celiprolol is a beta-blocker for the management of hypertension and angina pectoris.

作用机制

Celiprolol is a vasoactive beta-1 selective adrenoceptor antagonist with partial beta-2 agonist activity. The beta-2 agonist activity is thought to account for its mild vasodilating properties. It lowers blood pressure in hypertensive patients at rest and on exercise. The effects on heart rate and cardiac output are dependent on the pre-existing background level of sympathetic tone. Under conditions of stress such as exercise, celiprolol attenuates chronotropic and inotropic responses to sympathetic stimulation. However, at rest minimal impairment of cardiac function is seen.

适应症

Celiprolol is indicated for the management of mild to moderate hypertension and effort-induced angina pectoris.

• Angina Pectoris
• Hypertension