Autologous cultured chondrocytes (Carticel)

概览

Autologous cultured chondrocytes is a cell therapy used to treat damage to cartilage in the knees.

作用机制

Chrondrocytes are collected from the patient's femoral articular cartilage and isolated cells are expanded through cell culture in vitro. Multiplied chrondrocytes are implanted into articular cartilage defects beneath an autologous periosteal flap. Cells produce hyaline-like cartilage that mainly consists of type II collagen. Type II collagen maintain the macromolecular framework in the extracellular matrix that gives integrity to surrounding hyaline cartilage. The therapy repairs damaged cartilage and restores functional and mechanical ability to withstand compressional, tensile, and shear forces.

适应症

in Autologous cultured chondrocytes are indicated the repair of symptomatic, single or multiple full-thickness cartilage defects of the knee with or without bone involvement in adults aged 55 years and less. They are not indicated for use in joints other than the knee.

• Articular Cartilage Defects in the Knee Joint