Marsam pharmaceuticals llc, Watson laboratories inc, Baxter healthcare corp anesthesia critical care, Ferndale laboratories inc, Forest laboratories inc, Able laboratories inc, American therapeutics inc, Ascot hosp pharmaceuticals inc div travenol laboratories inc, Clonmel healthcare ltd, Heather drug co inc, Hetero drugs ltd, Impax laboratories inc, Inwood laboratories inc sub forest laboratories inc, Ivax pharmaceuticals inc sub teva pharmaceuticals usa, Kv pharmaceutical co, Lannett co inc, Mutual pharmaceutical co inc, Mylan pharmaceuticals inc, Nylos trading co inc, Pharmeral inc, Pioneer pharmaceuticals inc, Purepac pharmaceutical co, Roxane laboratories inc, Sandoz inc, Solco healthcare us llc, Solvay pharmaceuticals, Superpharm corp, Tablicaps inc, Upsher smith laboratories inc, Vintage pharmaceuticals inc, West ward pharmaceutical corp, Schwarz pharma inc • Methocarbamol tablets and intramuscular injections are indicated in the United States as an adjunct to rest, physical therapy, and other measures for the relief of discomforts associated with acute, painful musculoskeletal conditions. Oral methocarbamol in America may be given up to 1500mg 4 times daily for 2-3 days. In Canada, methocarbamol containing oral formulations are sold over the counter for pain associated with muscle spasm. However, if these combination formulations include codeine, they are prescription only.
Methocarbamol is a CNS depressant indicated with rest, physical therapy and other treatments to control the discomfort associated with various acute musculoskeletal conditions.
The mechanism of action of methocarbamol is thought to be dependant on its central nervous system depressant activity. This action may be mediated through blocking spinal polysynaptic reflexes, decreasing nerve transmission in spinal and supraspinal polysynaptic pathways, and prolonging the refractory period of muscle cells. Methocarbamol has been found to have no effect on contraction of muscle fibres, motor end plates, or nerve fibres.
