苯佐那酯

概览

Benzonatate is a non-narcotic oral antitussive drug used to suppress coughing.

作用机制

Benzonatate is a local anesthetic drug that acts peripherally by anesthetizing and reducing the activity of vagal stretch receptors or nerve fibres located in the respiratory passages, lungs, and pleura. Once the stretch receptors are stimulated, they send impulses to the cough centre located in the medulla via an afferent pathway consisting of sensory nerve fibres or the vagus nerve. The efferent signal is then generated that sends impulses to the expiratory muscles to produce a cough. Anesthetizing these receptors by benzonatate results in the inhibition of the cough reflex activity and cough production. Benzonatate also inhibits the transmission of impulses of the cough reflex in the vagal nuclei of the medulla. There are several proposed mechanisms of benzonatate; it is also a potent voltage-gated sodium channel inhibitor.

适应症

用于急性支气管炎、支气管哮喘、肺炎、肺癌索引起的刺激性干咳、阵咳等，也可用于支气管镜、喉镜或支气管造影前预防咳嗽。

• Cough