尼伐地平

概览

Nilvadipine is a calcium channel blocker used to manage arterial hypertension.

作用机制

Nilvadipine inhibits the influx of extracellular calcium through myocardial and vascular membrane pores by physically plugging the channel. The decrease in intracellular calcium inhibits the contractile processes of smooth muscle cells, causing dilation of the coronary and systemic arteries, increased oxygen delivery to the myocardial tissue, decreased total peripheral resistance, decreased systemic blood pressure, and decreased afterload.

适应症

用于防治高血压、心绞痛、脑血管痉挛及缺血性心脏病。

• Hypertension Arterial