西咪替丁 (Good Sense Heartburn Relief, Tagamet)

概览

Cimetidine is a histamine H2 receptor antagonist used to manage GERD, peptic ulcer disease, and indigestion.

作用机制

Cimetidine binds to an H-receptor located on the basolateral membrane of the gastric parietal cell, blocking histamine effects. This competitive inhibition results in reduced gastric acid secretion and a reduction in gastric volume and acidity.

适应症

Cimetidine is indicated to reduce gastric acid secretion and to treat the following disease states: duodenal ulcers, non-malignant gastric ulcers, gastroesophageal reflux disease, and pathological hypersecretion associated with Zollinger-Ellison Syndrome, systemic mastocytosis, and multiple endocrine adenomas. It is indicated for prophylaxis of recurrent gastric or duodenal ulcers, as adjunctive therapy in the management of cystic fibrosis in children, and to treat NSAID induced lesions and gastrointestinal symptoms.

• Cystic Fibrosis (CF)
• Gastric hypersecretion
• Gastro-esophageal Reflux Disease (GERD)
• Gastrointestinal Symptoms
• Heartburn
• Active Duodenal ulcer
• Benign gastric ulcers
• Develop NSAID-induced gastric ulcers
• Recurrent Ulcers, Duodenal and Gastric