西拉普利 (Inhibace)

概览

Cilazapril is an ACE inhibitor used for the management of hypertension and heart failure.

作用机制

Cilazapril is a pyridazine ACE inhibitor. It competes with angiotensin I for binding at the angiotensin-converting enzyme, blocking the conversion of angiotensin I to angiotensin II. As angiotensin II is a vasoconstrictor and a negative feedback mediator for renin activity, lower angiotensin II levels results in a decrease in blood pressure, an increase in renin activity, and stimulation of baroreceptor reflex mechanisms. Kininase II, an enzyme which degrades the vasodilator bradykinin, is identical to ACE and may also be inhibited.

适应症

Cilazapril is an ACE inhibtor class drug used in the treatment of hypertension and heart failure.

• Congestive Heart Failure (CHF)
• Hypertension
• Mild Essential Hypertension
• Moderate Essential Hypertension